Buffalo Bills 2025 Schedule. What is the 2025 nfl schedule for the buffalo bills, how does their strength of schedule stack up, and what is our record prediction? This will be the first time the buffalo bills play at home in week 1 since 2021 when.

The bills will be opening at home at highmark stadium against the arizona cardinals. Full buffalo bills schedule for the 2025 season including dates, opponents, game time and game result information.